منابع مشابه
HBV genotypes and outcome of HBV infection.
We read with interest the editorial on the correlation between hepatitis B virus (HBV) genotypes and outcome of HBV infection by Fung and Lok.1 This article made a succinct outline of the epidemiology of HBV genotypes and their association with hepatitis B e antigen seroconversion, activity of liver disease, and response to treatment. We believe that this article will be helpful to hepatologist...
متن کاملCommon variants of the TLR9 gene influence the clinical course of HBV infection.
Hepatitis B virus (HBV) infection leads to the development of liver inflammation, causing morbidity and mortality. Multiple factors influence HBV progression, including genetic factors. Toll-like receptor (TLR)9 plays a key role in innate immunity, and mutations in the genes encoding this receptor have been associated with liver damage progression. Our study aimed to investigate one-tag single ...
متن کاملEffect of hepatitis B virus (HBV) infection on the course of pregnancy and newborns’ health status
INTRODUCTION The effect of chronic hepatitis B virus (HBV) infection on pregnancy is not clear. Hepatitis B virus infection of newborns in the case of natural delivery occurs in 70-90% of cases. Risk factors of infection are the presence of serum HBeAg and HBV DNA level above 107 IU/ml. Active and passive prevention protect more than 95% of neonates born to mothers infected with HBV. The aim of...
متن کاملG-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection.
BACKGROUND The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like family of cytidine deaminases induce G-to-A hypermutation in hepatitis B virus (HBV) genomes and play a role in innate antiviral immunity. The clinical relevance of this protein family is unknown. METHODS We analyzed 33 instances in which 17 patients with chronic HBV infection experienced >2 increases of ...
متن کاملTherapeutic Direction and Issues Regarding HBV Infection
With up to 400 million affected people worldwide, chronic hepatitis B virus (HBV) infection is still a major health care problem. During the last decade, several novel therapeutic approaches have been developed and evaluated. In most regions of the world, interferon-α (IFN-α), and nucleos(t)ide analogues are currently approved. Despite major improvements, none of the existing therapies is optim...
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ژورنال
عنوان ژورنال: The Journal of Pediatrics
سال: 2014
ISSN: 0022-3476
DOI: 10.1016/j.jpeds.2014.07.052